Activin Receptors

Receptors for ACTIVINS are membrane protein kinases belonging to the family of PROTEIN-SERINE-THREONINE KINASES, thus also named activin receptor-like kinases (ALK's). Activin receptors also bind TRANSFORMING GROWTH FACTOR BETA. As those transmembrane receptors of the TGF-beta superfamily (RECEPTORS, TRANSFORMING GROWTH FACTOR BETA), ALK's consist of two different but related protein kinases, Type I and Type II. Activins initiate cellular signal transduction by first binding to the type II receptors (ACTIVIN RECEPTORS, TYPE II ) which then recruit and phosphorylate the type I receptors (ACTIVIN RECEPTORS, TYPE I ) with subsequent activation of the type I kinase activity.

Also Known As:

Activin Receptor; Activin Receptor-like Kinase; Receptor, Activin; Activin Receptor Like Kinases; Activin Receptor like Kinase; Kinase, Activin Receptor-like; Kinases, Activin Receptor-Like; Receptor-Like Kinases, Activin; Receptor-like Kinase, Activin; Receptors, Activin; Activin Receptor-Like Kinases

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9677
        Protein Serine-Threonine Kinases: 3588
        Activin Receptors: 423
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Peptide Receptors: 1159
        Growth Factor Receptors: 2663
        Transforming Growth Factor beta Receptors: 836
        Activin Receptors: 423
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein Serine-Threonine Kinases: 3588
      - Activin Receptors: 423

C D Wierikx Selected Research

C D Wierikx Research Topics

Disease

Drug/Important Bio-Agent (IBA)